Effects Of Genome Structure And Sequence On The Generation Of Variation And Evolution, Volume 1267 (Annals Of The New York Academy Of Sciences)

Effects of Genome Structure and Sequence on the Generation of Variation and Evolution, Volume 1267 (Annals of the New York Academy of Sciences)

The structure of DNA varies along its sequence, which can leadto sequence-dependent variations in the fidelity of DNA copying andrepair. And because the probability of distinct classes ofmutations varies along a DNA sequence, variation that affectsfitness will have evolutionary implications, as selection acts onheritable variation.

This Annals volume brings together a broad interdisciplinarygroup of researchers to explore the impact of increasingunderstanding of DNA structure, repair, replication, andorganization on interrelated subjects ranging from evolution, todependence of the effect of mutagens on environmental and sequencecontext, to noncanonical forms of information representation ingenomes.

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