Membrane Structural Biology: With Biochemical And Biophysical Foundations

Membrane Structural Biology: With Biochemical And Biophysical Foundations

Membrane Structural Biology brings together a physicochemical analysis of the membrane with the latest structural biology on membrane lipids and proteins to offer an exciting portrayal of biomembranes. Written with remarkable clarity, this text appears at a time when membranes have moved back into the scientific spotlight and will provide a unique foundation for advanced students and working scientists. The structure, function, and biogenesis of membrane lipids and proteins are examined, bioinformatics and computational approaches to membrane components are introduced, and the high-resolution structures that are giving new insights into the vital roles membranes play are discussed. The many correlations between membrane research and human health are discussed and key themes for future work in this area are identified. Membrane structural biology is poised to answer many basic and applied questions and this cutting-edge text will provide a solid grounding for all those working in this field.Review"In summary, the author has done a remarkable job collecting information and synthesizing it into a readable, thorough, and most timely book for academic curricula."D.A. Rintoul, Choice"Full of well-chosen colour figures, beautifully reproduced, making full use of the range of high-resolution structures now available for membrane proteins...What is unique about this book is its concentration on structure and on how structure helps to explain function. There is also more explanation of the physical chemical background to membranes and lipid bilayers than is found in other, more general textbooks."Anthony Lee, University of Southampton, Microbiology Today"This sophisticated new text presents biological, chemical and physical perspectives at an advanced level while being a pleasure to read. It is very up-to-date, with an organization that is novel but logical."Professor Stanley Parsons, University of California Santa Barbara"In this book, Mary Luckey did a remarkable job of synthesizing an incredible amount of up-to-date information. The book will be extremely useful to research scientists, graduate students, and even undergraduates interested in understanding how biological membranes function."Professor Hiroshi Nikaido, U. C. Berkeley"Luckey has, courageously (I should say, heroically), decided to write a single-author book, integrating the results of biological, biochemical and biophysical methods into a treatise of some 300 pages. The result is a well-balanced overview of the structures and the various biological activities of membranes which a multi-author book cannot provide. The subjects are clearly structured, the figures informative and vivid."Professor J. P. Rosenbusch, Biozentrum, University of Basel"?a well-balanced, thorough, and up-to-date treatment of membrane proteins and their bilayer environment. This is a badly needed contribution that encompasses most of the many breakthroughs that have taken place over the past 15 years in membrane protein structural, computational, and cell biology."Professor Chuck Sanders, Vanderbilt University"The volume impressively combines lucid summaries of basic principals and concise explanations of many recent developments in our understanding of membranes. Important background about concepts or techniques is effectively presented in ?boxes? that supplement the main text. The text is enriched by descriptions of the history of key concepts or advances. The burgeoning amount of structural information about membrane components, particularly three-dimensional structures of membrane proteins, is effectively incorporated into every aspect of this volume."Gerald L. Hazelbauer, Professor and Chair, Department of Biochemistry, University of Missouri"Unlike texts on the subject that have appeared in the interim that are multi-authored or highly specialized, Mary Luckey?s new text achieves breadth without sacrificing depth, is coherent, current, comprehen