Title
7,8Dihydroneopterin inhibition of cell death in atherosclerosis: Antioxidants in heart disease,Used
Delivery time: 8-12 business days (International)
The death of macrophages is important in the development of atherosclerosis, leading to the growth of the lipid core of the plaque. Cell death is due principally to the toxicity of oxidised LDL. However, cells may have a protective mechanism in the production of antioxidant 7,8dihydroneopterin (78NP). THP1 and U937 monocytes and macrophages were incubated with AAPH or oxidised LDL and loss of cell viability, total reduced thiols and cell death characteristics measured. Upon addition of 78NP, viability loss was decreased in the U937 cells only. The protective effect of 78NP may be dependent on its ability to inhibit thiol loss. All cell types produced 78NP after stimulation with IFN?. However, inclusion of IFN? did not prevent cell viability loss during exposure to oxLDL. 78NP is able to protect cells from viability loss generated by oxLDL in some circumstances. However, the evidence presented does not support the hypothesis that 78NP would be able to protect macrophages from cell death in the plaque. This work should be useful to those interested in the development of atherosclerosis and the contribution to its progression of macrophages, free radicals and oxidative stress.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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