Title
A Functional Study of Notch Signaling in Brain Cancer Stemlike Cells,Used
Delivery time: 8-12 business days (International)
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)like properties has been reported in GBM. It is hypothesized that these so called brain cancer stemlike cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stemlike cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures.
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⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.
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Shipping & Returns
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.