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Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials.New to the Second Edition Twelve new chapters covering blinded and semiblinded sample size reestimation design, pickthewinners design, biomarkerinformed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more More analytical methods for Kstage adaptive designs, multipleendpoint adaptive design, survival modeling, and adaptive treatment switching New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive doseescalation trials Twenty new SAS macros and R functions Enhanced endofchapter problems that give readers handson practice addressing issues encountered in designing reallife adaptive trialsCovering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with uptodate details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.
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birth defects, or other reproductive harm.
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