Title
Aldostrone, Rcepteurs Corticostrodes et Hypertension Artrielle: Apports des modles conditionnels transgniques (Omn.Pre,Used
Delivery time: 8-12 business days (International)
Laldostrone et les glucocorticodes jouent un rle majeur dans la rgulation de la pression artrielle. Les rcepteurs minralo(MR) et glucocorticodes (GR) sont des facteurs de transcription contrlant la rabsorption de Na+ dans le rein. Lobjectif de ma thse est dtudier in vivo les rles respectifs des rcepteurs GR et MR dans le rein et dans lendothlium vasculaire, laide de modles transgniques conditionnels permettant de surexprimer soit le MR, soit le GR de faon tissuspcifique. Nous montrons ainsi in vivo des effets spcifiques du GR dans la rgulation de lhomostasie du Na+ avec une modification de lexpression de diffrents canaux ioniques et/ou de leurs rgulateurs. Ces rsultats mettent en vidence des mcanismes de compensation se produisant dans les tubules distaux et connecteurs en amont, limitant les effets fonctionnels de la surexpression du GR dans le canal collecteur. La surexpression du MR dans lendothlium induit une hypertension artrielle modre, une augmentation de la contractilit vasculaire associe des modifications dexpression des canaux potassiques Ca2+dpendants, sans modification des paramtres structuraux vasculaires.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.
Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.