Amino Acids, Peptides And Proteins: Volume 34 (Specialist Periodical Reports, Volume 34),Used

Review '... a comprehensive review of important science at the chemistry/biology interface ...' J Chem Soc Perkin Transactions 2, No 11, 7 June 2001, p 1343'...this is an essential volume.' European Peptide Society Newsletter, Issue No 16, April 1997'...as usual this book is indispensable as the reference source for amino acid and peptide chemistry.' Chemistry and Industry September 1991'... a comprehensive review of important science at the chemistry/biology interface ...' Natural Product Reports, Vol 18, No 3, June 2001, p 359'The book has continued the excellence of previous volumes in this series and deserves a place in all chemistry libraries ...' J Chem Soc Perkin Transactions 1, No 5, 7 March 2002, p 703704'... the detailed breakdown of the Contents enables fast and efficient searching ... excellent value for money.' European Peptide Society Newsletter, Issue No 21, June 1999 Product Description In an everincreasing domain of activity, Amino Acids, Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Volume 34 provides a review of literature published during 2001. Comprising a comprehensive review of significant developments at this biology/chemistry interface, each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters, ranging from current trends in their synthesis and conformational and structural analysis, to peptidomimetics and the discovery of peptiderelated molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters, whilst periodic chapters on metal complexes of amino acids, peptides and betalactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the subdivision of chapters into discrete subject areas, allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia will find this an indispensable reference source. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, indepth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis. Excerpt. Reprinted by permission. All rights reserved. Amino Acids, Peptides and Proteins Volume 34A Review of the Literature Published during 2001By G.C. Barrett, J.S. DaviesThe Royal Society of ChemistryCopyright 2003 The Royal Society of ChemistryAll rights reserved.ISBN: 9780854042425ContentsPeptide Synthesis By Donald T. Elmore, 1, Chapter 2 Analogue and Conformational Studies on Peptides, Hormones and Other Biologically Active Peptides By Botond Penke, Gbor Tth and Gyrgyi Vradi, 55, Chapter 3 Cyclic, Modified and Conjugated Peptides By John S. Davies, 149, Chapter 4 Proteins By Graham C. Barrett, 219, CHAPTER 1Peptide SynthesisBY DONALD T. ELMORE1 IntroductionAs in the previous Report, many reviews have been published. Some relate to several sections of this article whereas others are cognate to particular sections as follows: Section 2.1, Section 2.3, Section 2.4, Section 2.5, Section 2.6, Section 2.7, Section 3.1, Section 3.2, Section 3.3, Section 3.4, Section 3.5, Section 3.6, Section 3.8, Section 3.9 and Section 3.9..2 Methods2.1 Aminogroup Protection. It often happens in chemistry that a technique that has been regarded as pass for some years, is slightly modified and resumes its former status in the literature. Protection of the aamino group by the phthaloyl group is a recent example. The need for rather vigorous conditions in order to effect removal with h