Androgenresponsive Genes In Prostate Cancer: Regulation, Function And Clinical Applications,Used

Androgenresponsive Genes In Prostate Cancer: Regulation, Function And Clinical Applications,Used

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Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgendependent DNAbinding transcription factor that regulates the expression of androgenresponsive genes. Identification and characterization of androgenresponsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volume provides critical information from well respected experts in the field. Some of the exciting topics include the new understanding of mechanisms underlining the regulation of androgenresponsive gene expression, and functions of various androgenresponsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelialtomesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgenresponsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with an interest in androgen action and prostate cancer.

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