Title
Antiinflammatory Agents of Aegiceras corniculatum:Mechanism of Action: Biochemical and Cellular Mechanism via production of Eic,Used
Delivery time: 8-12 business days (International)
This study is designed to explore antiinflammatory potential of Aegiceras corniculatum and its mechanism of action against various proinflammatory mediators. Rat paw edema and peritonitis model(s) were employed for in vivo studies and for in vitro study human platelets and rat neutrophils were stimulated with Ca+2ionophore for production of inflammatory metabolites of CyclooxygenaseI and Lipoxygenases pathways. Methanol extract constituting lignans and saponins caused ~90% reduction in carrageenan and PGE2 induced paw edema in rats and COXI metabolites 12HHT in human platelets. Hexane extract exerts its antiinflammatory effect on Arachidonic acid metabolites by inhibiting both types of lipoxygenases due to presence of benzoquinones. Ethyl acetate extract has implicated as a dual inhibitor of both COXI and 5LOX and this effect attributed to pentacyclic triterpenes and flavonoids. It also ameliorate histamine and serotonin release from mast cells and leukocytes infiltration. Additionally, these extracts antagonize the oxidative stress in human neutrophils via interference with NADPH oxidase pathways. Thus Aegiceras corniculatum is a potential candidate for drug discovery.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
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This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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