Title
betaArrestin/RezeptorInteraktionen: Ein endogenes "Werkzeug" ligandenspezifischer Signaltransduktion (German Edition),Used
Delivery time: 8-12 business days (International)
Die Bedeutung der ?Arrestine als multifunktionelle Adapterproteine GPCRvermittelter Signaltransduktion hat in den letzten Jahren immer mehr zugenommen. In der vorliegenden Arbeit lag der Schwerpunkt auf der Untersuchung der molekularen Basis sowie der Ligandenabhngigkeit sowohl der ?Arrestin/RezeptorInteraktion als auch ?Arrestin(un)abhngiger Signaltransduktionsmechanismen. Durch Mutationsanalysen konnten Ser 352/Thr 358 im distalen CTerminus des P2Y1R als Schlsselstellen der ?ArrestinTranslokation und Internalisierung identifiziert werden, whrend ein oder mehrere Phosphorylierungsstellen im proximalen P2Y1R CTerminus die molekulare Grundlage der Rezeptordesensibilisierung darstellen. Im Gegensatz dazu stellen die Phosphorylierungsstellen zwischen den Positionen 355 und 364 essentielle Bereiche der ?ArrestinTranslokation an den ?2AR dar. Darberhinaus wurde gezeigt, dass die endogenen Agonisten am ?2AR bzw. dem P2Y2R verschiedene mit dem jeweiligen Rezeptor verknpfte GProtein bzw. ?Arrestinassoziierte Signalwege zu unterschiedlichem Ausma aktivieren (?biased agonism?).
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.