Title
Building the Bionic Knee: Using compressive stimulation to tissue engineer cartilage in a collagen composite biomaterial,Used
Sold by Ergodebooks, an authorized reseller.
Returns accepted within 30 days | support@ergodebooks.com
Shipping Information
- Free Standard Shipping — United States only
- Processing Time: 1–3 business days
- Estimated Delivery: 3–5 business days after dispatch
- Double-boxed, fully insured & discreetly packaged
- Tracking number sent via email once dispatched
- Orders over $250 require signature upon delivery. Taxes calculated at checkout.
Returns & Refund
Returns accepted within 30 days of delivery.
Damaged or Defective Item
Free return shipping + replacement or full refund
Wrong Item Received
Free return shipping + replacement or full refund
Change of Mind
Return shipping at customer's expense · 25% restocking fee applies
Payment Option
Cartilage is a connective tissue integral to the functioning of joints. A promising step in treating defective cartilage is the implantation of autologous bone marrow stem cells at the defect site. When carried by an appropriate scaffold to provide chondrogenic signals, bone marrow stem cells can differentiate into cartilage. Previous studies show that cells seeded in hydrogels without the inclusion of fibers experience cellmediated contraction that leads swiftly to cell mediated death; the fibers are also considered key to improving mechanical strength of hydrogels. However, after three weeks in vitro in a collagen gel 3D matrix, cells seeded in gels without fibers did not have significantly different cell viability percentages than cells seeded in gels with flat fibers or round fibers. Additionally, compressive testing at 10% strain indicated that the equilibrium stresses of gels with no fibers was significantly higher than equilibrium stresses of gels containing flat fibers. Therefore, the inclusion of fibers and the use of compressive stimulation conditioning may not be any more effective than simple tissue engineered constructs of cellseeded collagen gels.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.