Title
Causes and Consequences of Genomic Instability in Prostate Cancer: An exploration of the mechanisms and impact of genomic aberra,Used
Delivery time: 8-12 business days (International)
The evolution of prostate cancer from normal epithelium via prostatic intraepithelial neoplasia to invasive carcinoma is characterised by particular genomic abnormalities that are predominantly generated in the preneoplastic phase. Telomere dysfunction is thought to be a major contributor to the cause of these alterations. This thesis clarifies the association of telomere dysfunction with markers of genomic instability such as abnormalities of chromosome 8, PTEN deletions and TMPRSSS2ERG aberrations as well as HPIN outcome. A previously unrecognised association between the telomere length in various types of prostatic epithelia and adjacent stroma is defined, suggesting evidence of a microenvironmental field effect. Therefore there are important avenues for further research to determine the nature of barriers to the evolution of prostatic carcinogenesis such as oncogene and telomereinduced senescence that may be exploited for therapeutic gain. These understandings may also help tailor management for prostate cancer such as risk stratification for men with HPIN and the use of targeted agents.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.