Title
Cell Biology of the Axon (Results and Problems in Cell Differentiation, 48),Used
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Product Description Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGFs role in trophicdependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a synuclein as a mechanism for accumulation of Lewy body inclusions in synucleinopathies; (IVa) occurrence and organization of discrete ribosomecontaining domains in axons, (IVb) endogenous mRNAs, classes of proteins translated locally, and RNP trafficking in axons, (IVc) importance of locally synthesized nuclear encoded mitochondrial proteins for maintenance, function and survival of axons, (IVd) occurrence of RNA trafficking from glial cells to axons, and significance glial RNA transcripts may play in expression in axons and axon terminals, (IVe) RNA trafficking and localization of RNA transcripts in axonal growth cones, and signaling pathways that modulate local protein synthesis for directional elongation, and (IVf) genetic and molecular defects underlying spinal muscular atrophy, and roles that SMN gene product plays as a molecular chaperone in mRNA transport and translation; (Va) injuryinduced local synthesis of a protein forming a retrograde signaling complex in axons to stimulate regeneration, and (Vb) endogenous and exogenous factors that condition axonal regenerative capacity in PNS and CNS, including injuryinduced activation of specific genes governing regeneration.Emergent complexities revealed in this volume compel a major revision in the traditional conceptual model of the axons intrinsic makeup and capacities. From the Back Cover Recent years have witnessed striking advances in research on axons at a cellular level that substantially impact our current understanding of axonal biology. Newer findings and their ramifications are critically reviewed in the 16 chapters of this volume by authors highly qualified by virtue of their scientific contributions to research areas they know and write about. Five basic areas (I to V) germane to axonal biology are highlighted, beginning with (I) signaling interactions mediating myelination, and differentiation of axonal membrane domains; (IIa) issues surrounding organization and transport dynamics of neurofilaments in axons, (IIb) mechanisms regulating microtubule organization and dynamics, misregulation of which causes axonal degeneration, and (IIc) the roles actin binding proteins play in regulating organization and functions of the actin filament system in mature and growing axons; (IIIa) myosin motor proteins and cargoes intrinsic to the axon compartment, (IIIb) mitochondrial transport motors, and imperatives governing transport dynamics and directional delivery, (IIIc) mechanisms mediating retrograde signaling associated with NGFs role in trophicdependent neuronal survival, and (IIId) potential for impaired subcellular targeting of a synuclein as a mechanism for accumulation of Lewy bo
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- Q: What is the main focus of 'Cell Biology of the Axon'? A: The book primarily focuses on recent advancements in axonal biology, reviewing significant findings related to axonal signaling, structure, and function.
- Q: Who are the authors of this volume? A: The volume is authored by Edward Koenig, along with other contributors who are experts in their respective fields of axonal research.
- Q: How many pages does the book contain? A: The book contains a total of 376 pages.
- Q: What is the publication date of this book? A: The book was published on September 11, 2009.
- Q: What type of binding does this book have? A: This book is bound in hardcover.
- Q: Is this book suitable for beginners in cell biology? A: This book is primarily aimed at researchers and professionals in the field; it may be complex for beginners without a background in cell biology.
- Q: What topics are covered in the chapters of this book? A: The chapters cover various topics such as myelination, neurofilament dynamics, microtubule organization, mitochondrial transport, and local protein synthesis in axons.
- Q: Is there any specific focus on axonal injury and regeneration? A: Yes, the book discusses injury-induced protein synthesis and factors affecting axonal regenerative capacity in both peripheral and central nervous systems.
- Q: What is the significance of RNA trafficking in axons as described in the book? A: The book highlights the importance of RNA trafficking from glial cells to axons and its role in local protein synthesis critical for axonal function.
- Q: Can this book help in understanding neurodegenerative diseases? A: Yes, the book addresses mechanisms related to axonal degeneration and conditions like synucleinopathies, providing insights relevant to neurodegenerative diseases.