Title
Chirurgisches Forum80: fr experimentelle und klinische Forschung, 97. Kongre der Deutchen Gesellschaft fr Chirurgie, Mnchen, 14.,Used
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22 polytraumatisierte und septische Patienten einer Intensiv station wurden im Rahmen einer Doppelblindstudie mit Pirenzepin bzw. Placebo behandelt. Alle Patienten wurden wahrend des Beob achtungszeitraumes in 14 Tagen dreimal endoskopiert. Ohne Pro phylaxe waren 100% StreBLasionen zu beobachten, 60% wiesen Blu tungen auf. Eine prophylaktische, intravenose PirenzepinGabe hatte einen eindeutig protektiven Effekt im Hinblick auf die StreBBlutung, Anzahl und Schweregrad der StreBLasionen. Summary Twentytwo severely ill patients with multinle injuries and sepsis were treated with IV pirenzepin or placebo 3 x 10 mg per day in the frame of the doubleblind study. All the patients were examined three times with endoscopy during the 14day ob servation period. In 100% of cases without prophylactic treat ment, stress lesions were observed, 60% of these cases had bleeding. A prophylactic IV pirenzepin application had an un mistakable protective effect regarding the stress bleeding, number and degree of stress lesions. Literatur 1. BRODIE, D.A.: Experimental peptic ulcer. Gastroenterology 55, 125134 (1968) 2. EINIG, D.: Ein neuer Sekretionshemmer. Ergebnisse einer Wir kungs und Vertraglichkeitsprufung mit Gastrozepin. Therapie woche 27,16301638 (1977) 3. HASTINGS, P.R., SKILLMAN, J.J., BUSHNELL, L.J. et al.: Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled randomized trial in 100 critically ill patients.
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