CoarseGrained Modeling of Biomolecules (Series in Computational Biophysics),Used

CoarseGrained Modeling of Biomolecules (Series in Computational Biophysics),Used

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"The chapters in this book survey the progress in simulating biomolecular dynamics. The images conjured up by this work are not yet universally loved, but are beginning to bring new insights into the study of biological structure and function. The future will decide whether this scientific movement can bring forth its Picasso or Modigliani." from the Foreword by Peter G. Wolynes, BullardWelch Foundation Professor of Science, Rice UniversityThis book highlights the stateofart in coarsegrained modeling of biomolecules, covering both fundamentals as well as various cutting edge applications. Coarsegraining of biomolecules is an area of rapid advances, with numerous new force fields having appeared recently and significant progress made in developing a systematic theory of coarsegraining. The contents start with first fundamental principles based on physics, then survey specific stateofart coarsegrained force fields of proteins and nucleic acids, and provide examples of exciting biological problems that are at large scale, and hence, only amenable to coarsegrained modeling.Introduces coarsegrained models of proteins and nucleic acids.Showcases applications such as genome packaging in nuclei and understanding ribosome dynamicsGives the physical foundations of coarsegrainingDemonstrates use of models for largescale assemblies in modern studiesGaregin A. Papoian is the first Monroe Martin Associate Professor with appointments in the Department of Chemistry and Biochemistry and the Institute for Physical Science and Technology at the University of Maryland.

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