Title
Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunittsforschung (German Edition),Used
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In lymphoiden Zellen Tbsensibilisierter Meerschweinchen sind sessile Antikrper vorhanden, die in der Lage sind nach Kontakt mit Tuberkulin Komplement zu binden. Dieser Nachweis ist sowohl fluorescenzserologisch als auch unter Verwendung von Extrakten aus solchen Zellen mit der Hmagglutination und der CoombsTechnik oder mit dem Konglutinations verfahren mglich. Sie knnen ferner mit dem Hmaggregationsverfahren nachgewiesen werden. Die sessilen Antikrper besitzen mindestens zwei, nach ihrer immunologischen Spezifitt und dem Mechanismus ihrer cytolytischen Funktion distinkte immunologische Spezifitten. Die eine ist gegen den Haupt bestandteil von Alttuberkulin (Tuberkulopolysaccharide) und die andere gegen den von gereinigtem Tuberkulin (Tuberkuloproteine) gerichtet. Beide Anti krper knnen auf weie Zellen nicht sensibilisierter Tiere bertragen werden. Sie sind mercaptothanolempfindlich und knnen deswegen den Antikrpern vom 19 STyp zugerechnet werden. Sie sind nicht identisch mit den cytophilen Antikrpern; auch scheint keine direkte kausale Beziehung zur Tuberkulin Hautreaktion zu bestehen. Ihre mgliche Bedeutung wird diskutiert. Lymphoide Zellen von Tbsensibilisierten Meerschweinchen enthalten auerdem noch einen Faktor, der in vitro Agglutinationsreaktion und in vivo PCAReaktionen hemmt. Literatur BAlL, 0.: bertragung der Tuberkulinempfindliehkeit. Z. Immun.Forseh. 1. Orig. 4,470 (1910). BLAZKOVEC, A. A., E. SORKIN, and J. L. TURK: A study of the passive eellular transfer of loeal eutaneous hypersensitivity. Int. Areh. Allergy 27, 289 (1965). BLOOM, B. R., and B. BENNETT: Meehanism of areaction in vitra associated with delayed type hypersensitivity. Scienee 153, 80 (1966). Delayed hypersensitivity in vitra: the meehanism of inhibition by antigen of eell migration. Fed. Prae. 25, 355 (1966).
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