Title
Deciphering the role of Yap4 phosphorylation under stress conditions: YAP4 is responsive to multiple stress conditions, being hi,Used
Delivery time: 8-12 business days (International)
Yap4 is a phosphoprotein highly induced upon the different stress conditions previously shown to increase the transcription of its gene (osmotic and oxidative stress, heat, arsenate exposure, etc) as well as during stationary phase. Yap4 is downstream the HOG Pathway and the General Stress Response and its phosphorylation is PKAdependent. Mutation of Yap4 residues T192 and S196 abolishes its phosphorylation, but not its nuclear localization or ability to partially rescue the hog1 severe osmosensitivity phenotype. Phosphorylation seems, however, to affect Yap4 stability as the nonphosphorylated form has a shorter halflife compared to the phosphorylated one. Removal of Yap4 leucine zipper abolishes its nuclear localization, suggesting that Yap4 dimerization could precede its nuclear import. This mechanism, however, does not involve the importin Pse1, previously shown to be responsible for Yap1 import into the nucleus. Future studies will clarify the mechanisms involved in Yap4 nuclear localization as well as its precise role in the yeast stress response.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
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