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Design Principles and Analysis Techniques for HRQoL Clinical TrialsSAS, R, and SPSS examples realistically show how to implement methodsFocusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical methods, such as mixed effect models, to their own studies. The author illustrates the implementation of the methods using the statistical software packages SAS, SPSS, and R.New to the Second EditionData sets available for download online, allowing readers to replicate the analyses presented in the text New chapter on testing models that involve moderation and mediation Revised discussions of multiple comparisons procedures that focus on the integration of healthrelated quality of life (HRQoL) outcomes with other study outcomes using gatekeeper strategies Recent methodological developments for the analysis of trials with missing data New chapter on quality adjusted lifeyears (QALYs) and QTWiST specific to clinical trials Additional examples of the implementation of basic models and other selected applications in R and SPSSThis edition continues to provide practical information for researchers directly involved in the design and analysis of HRQoL studies as well as for those who evaluate the design and interpret the results of HRQoL research. By following the examples in the book, readers will be able to apply the steps to their own trials.
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