Development of Herbal Drug Delivery System for Anticancer Therapy: Herbal Microspheres based Novel Drug Delivery System and its ,Used

Development of Herbal Drug Delivery System for Anticancer Therapy: Herbal Microspheres based Novel Drug Delivery System and its ,Used

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Herbal formulation is one of the novel drug delivery systems which possesses various advantages, including increasing drug solubility, enhancing dissolution rate, bioavailability, etc. Piper betle leaves Linn. (Family: Piperaceae) have been used in Chinese and Indian folk medicine for centuries, and recently been proposed to be used as a chemoprevention agent because of its antioxidant activity. The cytotoxicity of the aqueous extract of PBL was carried out to find its anticancer properties. A 3level full factorial design was employed to optimize the process conditions for formulating spherical shaped microspheres with higher encapsulation of drug. Formulation A1 to A9, B1 to B9 and C1 to C9 were prepared using three independent variables (drugpolymer ratio and stirring speed) and evaluated for dependent variables (shape, percentage yield, particle size, percentage drug loading and percentage cumulative release of drug in 24 h). The cytotoxicity studies on Hep2 cell line of sodium alginate microspheres exhibited a mean CTC50 of 95.20 g/ml. In case of BSA and chitosan microspheres this was found to be 90.00 and 94.00 g/ml respectively.

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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.

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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.

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Warranty

We provide a 2-year limited warranty, from the date of purchase for all our products.

If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.

This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).

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