Dimensin Fractal Reactiva de Partculas Farmacuticas: Aplicada al proceso de disolucin (Spanish Edition),Used

Dimensin Fractal Reactiva de Partculas Farmacuticas: Aplicada al proceso de disolucin (Spanish Edition),Used

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Brand: EAE Editorial Academia Espanola
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Las caractersticas superficiales y morfologicas de las partculas influyen en la manufactura de las formas farmacuticas y en propiedades derivadas tales como la disolucin. Para caracterizar morfologicamente estas partculas se recurre a descriptores clsicos, mientras que el proceso de disolucin se relaciona usualmente con el rea superficial. La dimensin fractal ofrece una nueva alternativa para la descripcin de formas complejas, a partir de ella es posible calcular la dimensin fractal superficial y relacionarla con la dimensin fractal reactiva, obtenindose iinformacin concerniente a los sitios activos disponibles en la superficie durante la disolucin y a la morfologa de la partcula. Con este anlisis es posible comprender algunos fenmenos que ocurren en la superficie de las partculas durante su disolucin, evidenciar la presencia o ausencia de poros y explicar comportamientos atpicos. Este libro contiene conceptos tericos y ejemplos que permiten comprender o predecir comportamientos de disolucin relacionados con la superficie y el tamao de las partculas.

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