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DNAtargeting Molecules as Therapeutic Agents (Chemical Biology, Volume 7),Used
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There have been remarkable advances towards discovering agents that exhibit selectivity and sequencespecificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies.The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNAinteractive agents and then the book provides examples of DNAinteractive molecules and technologies in development as therapeutic agents. DNAbinding metal complexes, peptide and polyamideDNA interactions, and gene targeting tools are some of the most compelling topics treated in depth.This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.
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