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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual druglike properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and indepth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, stepbystep guidance on property fundamentals, effects, structureproperty relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemists standpoint
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
I picked up this book for my grad studies in pharmacology and it's been super helpful. The sections on structure optimization really clarify complex concepts, making it easier to understand drug properties. Highly recommend it for anyone in the field!
A
Amina Kaur
Great Resource for Drug Design
I picked up this book for my grad studies in pharmacology and it's been super helpful. The sections on structure optimization really clarify complex concepts, making it easier to understand drug properties. Highly recommend it for anyone in the field!
A
Amina Kaur
Great Resource for Drug Design
I picked up this book for my grad studies in pharmacology and it's been super helpful. The sections on structure optimization really clarify complex concepts, making it easier to understand drug properties. Highly recommend it for anyone in the field!
D
David Chen
Informative but Dated
The content is quite informative, especially the parts about ADME processes. However, some sections feel a bit outdated, and I wish they had included more recent studies. It's still a useful reference, just be prepared to do some additional reading.
D
David Chen
Informative but Dated
The content is quite informative, especially the parts about ADME processes. However, some sections feel a bit outdated, and I wish they had included more recent studies. It's still a useful reference, just be prepared to do some additional reading.
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⚠️ California Proposition 65 Warning: Some products sold on this website may expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
