Title
EFFECT OF STRAIN AND STIFFNESS ON MATRIX REMODELLING GENES: 3D COLLAGEN CONSTRUCTS IN TISSUE ENGINEERING,Used
Delivery time: 8-12 business days (International)
The detail of how mechanical forces are transmitted to cells is poorly understood at present and represents a key missing link in Tissue Engineering. As cells attach to the fibrils in fibroblastseeded 3D collagen scaffolds they generate contractile forces to levels, which depend on cell type, attachment, density, growth factors and matrix stiffness. The aim here was to use external applied strain to increase matrix stiffness in collagen constructs. Embedded resident cells (from three different sites) were then subjected to specific mechanical loading regimes in scaffolds of increasing stiffness and matrix remodelling genes quantified as markers of mechanoregulatory cellular response. A strong corelation between substrate stiffness, mechanical loading and regulation of key ECM turnover genes was identified. This knowledge is crucial to successful tissue engineering outcomes. The differential lineage dependent response is a key finding and will have to be tailored depending on cell source and specific outcomes desired.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.