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If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
Customer service
All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com
Sale & Press
If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com
Electrospray ionization mass spectrometry (ESIMS) coupled to reversephase high performance liquid chromatography (RPHPLC) has emerged as one of the most powerful techniques for the analysis of biochemical and pharmaceutical compounds. Trifluoroacetic acid (TFA) is a commonly used additive in HPLC and LCMS analysis of basic compounds. However, TFA is known to suppress the ESI signals of analytes due to its ability to form strong gasphase ion pairs with positivelycharged analyte ions. This ionpairing process masks the sample positivelycharged analyte ions/cations from the ESIMS electric field by rendering them neutral. To overcome the signal suppression effect of TFA on basic compounds, we studied a simple and very effective means of minimizing the negative effect of TFA in analysis of aniline, caffeine, arginine and glutamine by addition of acetic acid or propionic acid to analyte solution containing 0.05% TFA. A factor of up to two fold signal enhancement (for arginine and glutamine) and full original signal recovery (for caffeine) were achieved.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
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