Title
Elucidating the role of MKK4 in neuronal apoptosis,Used
Delivery time: 8-12 business days (International)
Brain injury and neurological conditions are often associated with the excessive loss of neurones through apoptosis. In the brain, apoptosis is triggered by the activation of the cJun Nterminal protein kinase (JNK) signalling pathway by two mitogenactivated protein kinases (MAPKs): MKK4 and MKK7. While both proteins activate JNK in response to various extracellular stimuli, the biological functions of MKK4 and MKK7 in neuronal cell death remain to be identified. To advance our knowledge, I have developed two novel models of neuronal apoptosis using primary cultures of cortical neurones (MECN) and cerebellar granule neurones (CGN) in which MKK4 expression can be deleted. The absence of MKK4 significantly impedes stressinduced caspase3 activation in both cell types and partially protects neurones against stressinduced death and apoptosis. Furthermore, the loss of MKK4 leads to the inhibition of JNK3 activation following stress, and causes a marked decrease in the expression of cJun, a major target of JNK. This study suggests that MKK4 mediates stressinduced apoptosis in neurones through the activation of the JNK3/cJun pathway.
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Shipping & Returns
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
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