Title
Enamines as Intermediates in the Heterocyclic Synthesis: Novel Synthesis of Acrylamide Derivatives,Used
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The aim of this book is to synthesize some novel heterocyclic compounds starting from easily obtainable enamines. Therefore, the work have been divided into two parts; the first one is the synthesis of acryclic enamine, namely 2cyano3(dimethylamino)N(4phenylthiazol2yl)acrylamide and study its behavior towards some different nucleophiles to attain polyfunctionally substituted heterocyclic system of potential pharmaceutically interest. The second part is the synthesis of aminopyrazole derivative which has a latent enamine skeleton and study its reactivity towards various types of 1,3biselectophilic reagents to obtain annulated pyrazole derivatives which have expected pharmacological activity. The methods of synthesis and the synthetic mechanisms of the aforementioned reactions were well presented and the structures of these compounds were assessed by analytical and spectral data.
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