Title
Epigenetic Regulation of Asthma: Role of Stat3, Socs3 and IL6,Used
Delivery time: 8-12 business days (International)
Stat3, Socs3 and cytokines play an integral role in coordination and persistence of inflammation. However, a clear understanding of the role played by the Stat3/IL6 and Socs3 pathway in airway inflammation is lacking. We report the alteration in the status of expression and activation of Stat3 by Ovalbumin, and establish its relationship with Socs3 and IL6 in the lungs of mice with eosinophilic pulmonary inflammation and airway hyper responsiveness. As IL6 regulates the activity of DNA methyltransferases, we hypothesize that asthma is fallout of epigenetic alteration in Socs3. Here, the status of CpG methylation and histone acetylation in the Socs3 promoter of asthmatic lung was studied, as was the role of IL6 in altering these parameters.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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