
Title

Feedback model of extracellular dopamine concentration control: Extracellular dopamine concentration control: computational mode,Used
Delivery time: 8-12 business days (International)
Dopamine is one of the central neurotransmitters; its homeostatic concentration is maintained through release, uptake, and feedback. The extracellular dopamine concentration is regulated presynaptically by the dopamine transporter (DAT) and dopamine autoreceptors. The postsynaptic control is mediated by postsynaptic dopamine receptors. Dopamine is the subject of a numerous experimental studies. As a result, great deal of experimental data describing the components of dopamine system has been collected. This experimental data provides an excellent foundation for theoretical study to model complex dopamine system. Mathematical modeling was based on published pharmacokinetic parameters for dopamine uptake and receptor binding in rat striatum. It was demonstrated computationally that both uptake by DAT and negative feedback mediated by receptors are necessary components to maintain a low extracellular dopamine concentration under basal conditions. The mathematical modeling also showed the critical role of negative feedback to control stable extracellular dopamine concentration under conditions of increased/decreased dopamine release.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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