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Help
If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
Customer service
All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com
Sale & Press
If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com
Dopamine is one of the central neurotransmitters; its homeostatic concentration is maintained through release, uptake, and feedback. The extracellular dopamine concentration is regulated presynaptically by the dopamine transporter (DAT) and dopamine autoreceptors. The postsynaptic control is mediated by postsynaptic dopamine receptors. Dopamine is the subject of a numerous experimental studies. As a result, great deal of experimental data describing the components of dopamine system has been collected. This experimental data provides an excellent foundation for theoretical study to model complex dopamine system. Mathematical modeling was based on published pharmacokinetic parameters for dopamine uptake and receptor binding in rat striatum. It was demonstrated computationally that both uptake by DAT and negative feedback mediated by receptors are necessary components to maintain a low extracellular dopamine concentration under basal conditions. The mathematical modeling also showed the critical role of negative feedback to control stable extracellular dopamine concentration under conditions of increased/decreased dopamine release.
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