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Morphometrischstereologische Verfahren haben seit Mitte der 60er Jahre mehr und mehr Anwendung gefunden bei der ultrastrukturellen Analyse biologischmedizinischer Objek teo Besonders der Schweizer Arbeitsgruppe urn WEIBEL kommt das Verdienst zu, aus der Minera10gie und Geologie bekannte Verfahren ftir diesen Bereich nutzbar gemacht zu haben (s. WEIBEL, 1969). Dabei werden Anzahl, Oberflachen und Volurnenbestirnmungen an Zellen und intrazellularen Strukturen verschiedener Orga ne durchgeftihrt. Ziel dieser Verfahren sind reproduzierbare und objektivierbare Aussagen, die an Hand dieser drei MeB groBen tiber die untersuchten Objekte gewonnen werden konnen. Ein bestimmter Funktionsstatus ist durch eine ganze Reihe von Parametern charakterisiert. So ist etwa eine "normale" Leber klinisch, biochemisch, makroskopisch und histologisch erfaBt. Ihre Organstruktur und Zellmorphe prasentiert sich auch im elektronenmikroskopischen Bild in einer bestimmten, dazu korrelierenden Weise: Ze11zuordnung, Zellkontakte, Interzellularraurn, ZellgroBe und form sowie Anordnung, Gro Be und Anzahl von Zellorganellen spiegeln mit einer gewis sen Schwankungsbreite den Funktionszustand "Normalitat" wider. In analoger Weise sind funktionelle Alterationen oft mit Veranderungen des elektronenmikroskopischen Erschei nungsbildes vergesellschaftet. Eine Reihe von Noxen ftihrt z.B. bei Einwirkung auf die Leber zu typischen Scnadigungs mustern: Veranderungen am glatten und rauhwandigen endoplas matischen Retikulurn, vermehrte lysosomale Inklusionen, Mito chondrienlasionen, Vermehrung von Microbodies und Fettein schltissen usw.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
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