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This book introduces an integrated experimentalcomputational approach to investigate the mechanisms responsible for microbubbleinduced injury during mechanical ventilation of patients with Acute Lung Injury and Acute Respiratory Distress Syndrome. In this approach, a computational model was developed to account for a minimal level of complexity required, but with significantly complex dynamics such as fluidstructure interaction. Once validated, these quantitative models of respiratory physiology are then being used to interpret counterintuitive experimental data, suggest new avenues of investigation and develop novel patientspecific therapies. The author discusses key concepts and principles, such as cellular engineering and biomechanics, respiratory system, epithelial cell injury, multiscale computational modeling and molecular/cellular scale imaging and analysis. This textbook presents stateoftheart analytical and computational approaches to problems in fluidstructure interaction and free surface flow. This book should be an important reference for any researcher interested in the fundamental science and simulation techniques for flow in the respiratory system.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
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