
Title

Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Springer Theses),Used
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With the aim of providing a deeper insight into possible mechanisms of biological selforganization, this thesis presents new approaches to describe the process of selfassembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and nonequilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the proteinprotein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the selfassembly process of proteins. In the second part, by mapping the membranemediated forces into a simplified manybody system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this selforganizing process.
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This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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