Title
Formulation and Evaluation of Extended Release Tablet of Divalproex: Extended Release Tablet of Divalproex Sodium,Used
Delivery time: 8-12 business days (International)
The present study was aimed to develop an extended release matrix tablet of Divalproex sodium using hydrophilic polymer as release retarding agent. The formulation of Divalproex sodium matrix forming tablet was developed by using 2 factor 3 level full factorial design. The concentrations of HPMC K100M (10%, 12.5% & 15%), Eudragit L100 (10%, 12.5% & 15%) were selected as independent variables. The dependent variables selected were %drug released at 3hr, and %drug released at 12hr. As the drug has good flow property and compressibility, the direct compression method was employed to formulate the tablets. Tablets were evaluated for various physicochemical parameters. In vitro drug release study showed that batch F8 (HPMC K100M15%, Eudragit L10010%) was found to be optimized as it had almost identical dissolution profile with marketed product. Eudragit show synergism with HPMC K100M on drug release retardation and avoid the chances of burst release. The kinetic release treatment showed that Korsmeyer equation has shown of r2 = 0.988. Stability study of optimized batch F8 was conducted at accelerated conditions for one month and it was found to be stable.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.