Title
Function of LMP2B in EBVpositive Burkitt's Lymphoma: Virus and cancer (German Edition),Used
Delivery time: 8-12 business days (International)
EpsteinBarr virus (EBV) is a human ?herpesvirus that persists latently in the memory Bcell pool. EBV is linked to malignancies including Burkitts lymphoma (BL) where it expresses specific latency genes. Among these genes, latent membrane protein (LMP)2A and LMP2B seem to be involved in the regulation of EBV latency. LMP2A blocks Bcell receptor (BCR) signalling after its engagement, which activates as well lytic EBV infection. Therefore, LMP2A contributes to the persistence of EBV. By contrast, the function of LMP2B, a splice variant of LMP2A, is still not resolved. The experimental setup presented in this book revealed for the first time that silencing of LMP2B resulted in reduced expression of lytic EBV mRNA and proteins upon BCR crosslinking. By contrast, overexpression of LMP2B resulted in the opposite. We could further demonstrate that LMP2A and LMP2B physically interact and that LMP2B resides predominantly in intracellular compartments. In conclusion, these observations support the hypothesis that LMP2B exhibits a negative regulatory effect on the ability of LMP2A to maintain latent EBV by preventing the switch to lytic infection.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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