Title
Genetic Immunization & Cytokine Immunomodulation: Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB,Used
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In chronic parasitic infections, the interplay between the host and the parasite suggests immunosuppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses. This study aimed at exploring the immune response generated in BALB/c mice using genetic immunization technology. Immunomodulation by the codelivery of different cytokine genes (IFN?, IL12, IL4) was also investigated. Immunization by antigen B or its second subunit (EgAgB8/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN? cytokine in IFN? gene coimmunized mice indicates the efficiency of cytokine gene immunomodulation in skewing the response toward T helper type 1.
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