Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses),Used

Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (Springer Theses),Used

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SKU: DADAX3030008525
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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on TravellingWave Ion Mobility coupled with Mass Spectrometry (TWIMMS), and Xray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of CS coupling.

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