Title
HLA Expression in Leukemia: Status, Regulation & Therapeutic Implications of HLA Expression in Leukemia,Used
Delivery time: 8-12 business days (International)
Classical HLA class I (class Ia) downregulation may be the cause of immune escape mechanism by the cancer cells and is well documented in different cancers. Recently it is shown that in leukemia there is a locus specific HLA class Ia downregulation both at the antigenic and transcriptional level. As, so far, no mutation is recorded in HLA genes; so the reason may lies at the expression of different transcription factors (TRFs) that regulate its expression. Reports suggest that there is an alteration of the constitutive region binding TRFs of the HLA promoter in leukemia. Though there is upregulation of some inducible region binding TRFs, but they are unable to transcribe the HLA class Ia genes. This indicates the accessory role of the inducible binding TRFs. Absence of nonclassical HLA class I (class Ib) in leukemic cells may give us the molecular rationale for the success of NK cell mediated immunotherapy. Interestingly, neutrophils (PMNs) of normal volunteers in contact with leukemic cells showed HLA class II expression and oxidative damage towards the leukemic cells. So, PMNs can be utilized for the management of infections under the condition and for leukemia immunotherapy.
By changing our most important processes and
products, we have already made a big leap forward. This ranges from the
increased use of more sustainable fibers to the use of more
environmentally friendly printing processes to the development of
efficient waste management in our value chain.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.
For more information, please visit www.P65Warnings.ca.gov.
Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.
Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.