Title
Human STAT1 deficiencies: Description and characterisation of the different Human STAT1 deficiencies,Used
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The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN?, STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN?, STAT1 heterotrimerizes with STAT2 and ISGF3? to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN?inducedGAF complexes in antimycobacterial immunity and of IFN? induced ISGF3 complexes in the antiviral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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