Title
Hydrodynamic Analysis of Groucho QDomain: Physical Biochemistry techniques reveals an unexpected shape,Used
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The Groucho (Gro)/Transducinlikeenhancer of split (TLE) family of corepressors plays a significant role in the regulation of many cellular processes. Having no intrinsic DNAbinding activity, Gro/TLE interacts with various DNAbound repressor proteins to repress transcription. Gro/TLE possesses a conserved region known as the Qdomain, and this region has been shown to direct the oligomerization of Gro/TLE, which is required for repression. Although the Qdomain is required for oligomerization, its structural properties have never been fully characterized. Here, the Qdomain was tagged with a small ubiquitinrelated modifier protein (SUMO) to alleviate aggregation observed with the untagged Qdomain. Size exclusion chromatography (Gel Filtration) and analytical ultracentrifugations were performed. Results show that SUMOQ oligomerizes predominantly as a tetramer. However, significant heterogeneity is observed at high salt concentrations. Analysis of the hydrodynamic data suggest a markedly nonspherical structure.
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We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
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To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
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