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Bacterial CpGDNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpGDNA directly causes activation of these members of the innate immune system yielding in upregulation of costimulatory molecules and proinflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
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