Immunological Synapse (Current Topics In Microbiology And Immunology, 340),Used

Immunological Synapse (Current Topics In Microbiology And Immunology, 340),Used

In Stock
SKU: SONG364226185X
Brand: Springer
$155.53 $222.19
Save $66.66
Quantity
Add to wishlist
Add to compare

Processing time: 1-3 days

US Orders Ships in: 3-5 days

International Orders Ships in: 8-12 days

Return Policy: 15-days return on defective items

Payment Option
Payment Methods

Help

If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.

Customer service

All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com

Sale & Press

If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com

Product Description The proper physiological functioning of most eukaryotic cells requires their assembly into multicellular tissues that form organized organ systems. Cells of the immune system develop in bone marrow and lymphoid organs, but as the cells mature they leave these organs and circulate as single cells. Antigen receptors (TCRs) of T cells search for membrane MHC proteins that are bound to peptides derived from infectious pathogens or cellular transformations. The detection of such speci?c peptideMHC antigens initiates T cell activation, adhesion, and immuneeffectors functions. Studies of normal and transformed T cell lines and of T cells from transgenic mice led to comprehensive understanding of the mole lar basis of antigenreceptor recognition and signaling. In spite of these remarkable genetic and biochemical advances, other key physiological mechanisms that par cipate in sensing and decoding the immune context to induce the appropriate cellular immune responses remain unresolved. TCR recognition is tightly regulated to trigger sensitive but balanced T cell responses that result in the effective elimination of the pathogens while minimizing collateral damage to the host. The sensitivity of TCR recognition has to be properly tempered to prevent unintended activation by selfpeptideMHC complexes that cause autoimmune diseases. It is likely that once the TCR is engaged by a peptide MHC and TCR signaling begins, additional regulatory mechanisms, involving other receptors, would increase the ?delity of the response. From the Back Cover will follow

⚠️ WARNING (California Proposition 65):

This product may contain chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm.

For more information, please visit www.P65Warnings.ca.gov.

Recently Viewed