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If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
Customer service
All questions about your order, return and delivery must be sent to our customer service team by e-mail at yourstore@yourdomain.com
Sale & Press
If you are interested in selling our products, need more information about our brand or wish to make a collaboration, please contact us at press@yourdomain.com
The study examined the affect of cortisol on basal and cAMPstimulated in vitro steroidogenesis of rainbow trout (Oncorhynchus mykiss) ovarian follicles at different maturational stages. Basal and cAMPstimulated 17estradiol (E2) and testosterone (T) production was highest during the midvitellogenic (MV) stage, compared with early and latevitellogenic stages. Cortisol suppressed the basal steroid production in the MV stage, and suppressed cAMPstimulated steroid production in all three maturational stages. To determine whether cortisol exerts its effect on pregnenolone (P5) production, real time RTPCR was used to measure the expression of genes coding for steroidogenic acute regulatory (StAR) protein, and cytochrome P450scc. There was no significant affect of cortisol on the expression of either gene. To look for possible actions of cortisol on steroidogenic enzyme function, the effect of the glucocorticoid on the biotransformation of radiolabelled P5, and T was examined; cortisol appeared to suppress the aromatization of androgens to estrogens by a mechanism that is not fully understood.
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