Title
Increasing the immunostimulatory capacity of human leukemia cells: using RNA and Tolllike receptor ligands,Used
Delivery time: 8-12 business days (International)
The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Immunotherapy for leukemia is a promising targeted strategy to prevent relapse and to prolong the survival of leukemia patients by eliminating residual leukemic cells that survive standard therapy. However, in order to elicit effective immune responses during immunotherapy, the immune tolerance against leukemic cells needs to be broken. Mechanisms that contribute to immune tolerance are the lack of expression of costimulatory molecules by leukemic cells and the lack of danger signals in leukemic cells and/or in their microenvironment. Here, we studied the ability of RNA molecules or synthetic derivatives to increase the immunogenicity of acute myeloid leukemia (AML) cells and to break the nonresponsiveness of immune cells to AML cells, in the light of their potential future use in leukemia immunotherapy strategies.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Secure Payment
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.