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If you have any questions, you are always welcome to contact us. We'll get back to you as soon as possible, withing 24 hours on weekdays.
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Toxic cyanobacteria are abundant in marine and freshwaters including rivers, lakes and drinking water reservoirs. Dating back to George Franciss first publication in 1878, numerous cyanobacterial poisonings of aquatic and terrestrial animals as well as humans have been reported worldwide. This is especially true for Microcystins a group of serine/threoninespecific protein phosphatase inhibitors with more than 80 variants. Whereas the hepatotoxic potential of MicrocystinLR is well characterized, organ and cell type specific toxicity induced by other Microcystin variants is poorly understood. This study presented here clearly revealed that organic anion transporting polypeptides play a crucial role in the neuronal uptake of Microcystins and that the uptake and subsequent neurotoxicity is highly dependent on the Microcystin variant. If these observations can be extrapolated to the human, they not only explain the observed neurotoxicity in the Caruaru accident, but also highlight the problem of using only Microcystin LR, as the basis for Microcystin related human risk assessment.
⚠️ WARNING (California Proposition 65):
This product may contain chemicals known to the State of California to cause cancer,
birth defects, or other reproductive harm.
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⚠️ California Proposition 65 Warning: Some products sold on this website may expose you to chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
