Title
InSilico Screening of Potent Anticonvulsant Agents: Discovery of Potent Anticonvulsant Ligands as Dual NMDA and AMPA Receptors ,Used
Delivery time: 8-12 business days (International)
Epilepsy is a disorder of the central nervous system characterized by paroxysmal, excessive, hypersynchronous discharges of large numbers of neurons. To identify novel and potent anticonvulsant ligands, initially 2DQSAR,3DQSAR and pharmacophore models were generated using a series some prop2eneamido and 1acetylpyrazolin derivatives of aminobenzothiazole as anticonvulsants. To discover new hits, developed pharmacophore model was subjected to screen molecules from specs database. Screened hits which were showing good predicting activities according to both 2D and 3DQSAR models were subjected to docking screening. Gly/NMDA and AMPA receptors are effective and validated anticonvulsant targets and used to report the binding affinity of screened hit on Gly/NMDA, AMPA receptors. A representative set of 14 compounds with effective biological activity and good binding affinity on both NMDA and AMPA receptors were screen out which may potential lead for anticonvulsant activity.
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⚠️ WARNING (California Proposition 65):
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For more information, please visit www.P65Warnings.ca.gov.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.