Title
Investigation of cellular functions of tetraspanin CD63: Tetraspanin membrane protein CD63,Used
Delivery time: 8-12 business days (International)
The tetraspanins are a superfamily of widely expressed membrane proteins with four conserved transmembrane domains, small (EC1) and large (EC2) extracellular domains, and short cytoplasmic N and Ctermini. Tetraspanins have been linked to many basic cell processes including adhesion, motility, activation and fusion. However, the function of individual tetraspanins remains difficult to define. This project investigated the function of human tetraspanin CD63, by studying the behaviour of mutants transfected into model cell lines. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced. Initially, deletion and point mutants were used to investigate the role of the Cterminus, which contains a putative lysosomaltargeting/ internalisation motif (GYEVM). Cterminal mutants showed increased surface expression and decreased intracellular localisation relative to CD63Wt. Antibodyinduced internalisation was reduced in Cterminal deletion mutants and abolished in G/A and Y/A mutants, showing the crucial role of these residues in internalisation.
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Shipping & Returns
Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.
Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.
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If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
Warranty
We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
We accept payments with :
Visa, MasterCard, American Express, Paypal, Shopify Payments, Shop Pay and more.