Title
InvitroUntersuchung zur differentiellen Expression von RANK(L): Relevanz fr die Exklusivitt der Bisphosphonatassoziierten Nek,Used
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Beim RANKLiganden handelt es sich um ein regulatorisches Protein im Knochenmetabolismus, dessen Reduktion mit dem Auftreten von Kiefernekrosen nach langjhriger Bisphosphonattherapie einhergeht. Lokalisationsbezogen wird der RANKLigand in Osteoblasten unterschiedlicher entwicklungsgeschichtlicher Abstammung in vernderlicher Quantitt exprimiert. Ein kausaler Zusammenhang zwischen der Reduktion des RANKLiganden und der Ausprgung des Krankheitsbildes der Bisphosphonatassoziierten Kiefernekrose ist daher sehr wahrscheinlich. In vorliegender Untersuchung wurden die Auswirkungen des Aminobisphosphonats Pamidronat auf die RANKLExpression in Osteoblasten mesenchymaler im Vergleich zu Osteoblasten neuroektodermaler Abstammung, differentiell anhand eines invitroVersuches analysiert. Aufgrund positiver Effekte auf die Knochenregeneration bei nicht heilenden chronischen Wunden wurde das Mitogen PDGF als mgliches Therapeutikum zur Behandlung der Bisphosphonatassoziierten Kiefernekrose diskutiert.
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We provide a 2-year limited warranty, from the date of purchase for all our products.
If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.
This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).
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