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Throughout the world, cardiovascular diseases associated with ischemic and reperfusion organ injuries are among the main factors of human mortality. Hence, the analysis of mechanisms responsible for these injuries and the development of approaches to their prevention and treatment present a pressing problem for specialists in biology and medicine.This book is based on firsthand experience gained by the author and her research team during many years of experimental studies, supported by the analysis of abundant literature published between 1970 and 1999. It deals with the comparative assessment of ischemic and reperfusion injuries and their mechanisms in vitally important organs differing in their sensitivity to oxygen deficiency, metabolic activity, and provision with radicalgenerating and antioxidant system. A distinctive feature of the monograph, compared to previous studies in this field, is that attention is focused on the role of freeradical reactions, their place among other damaging factors (disturbances of energy metabolism, intensification of lipolysis and phospholipolysis, etc.), a detailed analysis of mechanisms responsible for the formation of free radicals during ischemia (the roles of electron transport pathways, radicalgenerating enzymes, macrophages, endothelial cells, etc,), and a general review of modern methods of antiradical and antiischemic therapy. None of the books published to date is characterized by such an approach to the problem.
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