Issledovanie mekhanizma organizatsii spiral'noy struktury oligopeptidov: S chego nachinaetsya al'faspiral'? (Russian Edition),Used

Issledovanie mekhanizma organizatsii spiral'noy struktury oligopeptidov: S chego nachinaetsya al'faspiral'? (Russian Edition),Used

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SKU: DADAX3847330411
Brand: LAP Lambert Academic Publishing
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Kak izvestno, vsya informatsiya, neobkhodimaya dlya svorachivaniya belka, soderzhitsya v posledovatel'nosti sostavlyayushchikh ego aminokislotnykh ostatkov. K nastoyashchemu vremeni khorosho izucheny individual'nye kharakteristiki vsekh 20 Laminokislot (struktura, spektral'nye i termodinamicheskie svoystva), a takzhe svoystva soten peptidov. Izvestna statistika raspredeleniya aminokislot v tekh ili inykh vtorichnykh strukturakh belka, izmereny kineticheskie kharakteristiki ryada stadiy ego svorachivaniya, odnako initsiiruyushchie nachala rannikh stadiy foldinga ostayutsya nedostatochno konkretizirovany. Nasha rabota posvyashchena issledovaniyu nachal'nykh etapov obrazovaniya al'faspiraley PolingaKori pri pomoshchi sovremennykh metodov komp'yuternogo modelirovaniya: kvantovokhimicheskogo i molekulyarnodinamicheskogo. Po nashey gipoteze, spiralizatsiyu initsiiruyut kislye aminokislotnye ostatki aspartat i glutamat, a terminiruyut osnovnye arginin, lizin i gistidin. V osnove etikh dvukh protsessov lezhat skhodnye mekhanizmy, khod protekaniya kotorykh my smodelirovali dlya raznykh peptidov i usloviy mikrookruzheniya.

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