Life Itself: Exploring The Realm Of The Living Cell

Hidden In A Nondescript Redbrick Building In Rockville, Maryland, Is The Most Unusual Warehouse In The World, A Bank Of Living Cells Called The American Type Culture Collection. Here, At 321 Degrees Below Zeroa Temperature At Which Life Abandons Its Vital Dance And Enters Limbo, But Without Dyingare Some 30,000 Vials Holding 60 Billion Living Forms In Suspended Animation, Including Mouse Kidney Cells, Turkey Blood Cells, Armadillo Spleen Cells, And Some 40 Billion Human Cells. These Cultured Cells Are Essential To Modern Biological Researchin Fact, Cells Today Are The Most Intimately Studied Life Forms In All Of Science, For Both Practical And Philosophical Reasons. For One, All Diseasefrom Cancer And The Common Cold, To Arthritis And Aidsstems From Cells Gone Awry. And Cell Research Not Only Promises A Cure For A Wide Variety Of Diseaseit Also Holds The Key To The Mystery Of Life Itself.In Life Itself, Boyce Rensberger, Science Writer For The Washington Post, Takes Readers To The Frontlines Of Cell Research With Some Of The Brightest Investigators In Molecular, Cellular, And Developmental Biology. Virtually All The Hottest Topics In Biomedical Research Are Covered Here, Such As How Do Cells And Their Minute Components Move? How Do The Body'S Cells Heal Wounds? What Is Cancer? Why Do Cells Die? And What Is The Nature Of Life? Readers Discover Thatcontrary To What We May Have Concluded From Pictures In Our High School Textbookscells Teem With Activity And That, Inside, They Are More Crowded With Components Than The Inside Of A Computer. We Learn That Scientists Now Know Of At Least Ten Molecular Motors That Move Things About Inside The Cellin Most Cells, This Motion Is Short Because The Cell Is Tiny, But In The Singlecelled Nerve Fibers That Run From The Base Of The Spinal Cord To The Toes (Measuring Three Or Four Feet In An Adult Human), Molecular Motors Can Take Several Days To Make The Trip. Rensberger Describes The Many Fascinating Kinds Of Cells Found In The Body, From Neural Crest Cells (Early In Embryonic Development, These Cells Crawl All Over The Embryo To The Sites Where They Will Pursue Their Fateas Nerve Cells, Or Cartilage, Or Skin), To Dust Cells (Nomadic Cells In The Lung That Swallow And Store Indigestible Particles, Then Migrate To The Gullet Where They Themselves Are Swallowed And Digested), To Natural Killer Cells (Millions Of Which Roam The Body Looking For Cancerous Cells). We Meet Many Of The Scientists Who Have Pioneered Cell Research, Such As Rita Levimontalcinian Italian Who, Shut Out Of Her Lab During World War Ii, Continued To Experiment In Her Bedroom At Home, Making The Discovery (Nerve Growth Factor) For Which She Won The Nobel Prizeand American Leonard Hayflick, Who Proved That All Human Cells (Except Cancer Cells) Invariably Die After About Fifty Divisions. Rensberger Also Provides An Illuminating Discussion Of Aidsrevealing Exactly Why This Virus Is So Difficult To Defeatand Of Cancer, Explaining That Before Cancer Can Start, A Whole Series Of Rare Events Must Occur, Events So Unlikely That It Seems A Wonder That Anyone Gets Cancer At All.The Solutions To The Most Pressing Challenges Facing Scientists Todayfrom The Efforts To Conquer Disease To The Quest To Understand Life Itselfwill Be Found In The Innermost Workings Of The Cell. In Life Itself, Boyce Rensberger Paints A Colorful And Fascinating Portrait Of Modern Research In This Vital Area, An Account Which Will Enthrall Anyone Interested In Stateoftheart Science Or The Incredible Workings Of The Human Body.