Lignans as Anticancer agents: Recent advances in the discovery and development of Lignans as Anticancer agents,Used

Lignans as Anticancer agents: Recent advances in the discovery and development of Lignans as Anticancer agents,Used

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Cancer, an abnormal and uncontrolled cell division, has engulfed the lives of unlimited people till date. Etoposide and Teniposide are podophyllotoxin derivatives and have been used clinically for treatment of refractory testicular tumor and cancer. These compounds arrests cell growth by DNA topo II inhibition, which causes double strand breaks in DNA and known as noninterclating topo II inhibitors. They have many side effects, such as myelosuppression, poor water solubility, and the development of resistance so modification is done on it at various sites. Podophyllotoxin contains a fivering system. Modification of the Aring gave compounds having significant activity but less than that of Etoposide, whereas modification of the Bring resulted in the loss of activity. Ering is essential for its anticancer activity and Dring in lactone form is preferred for better activity. The introduction of double bond in Cring lowers the activity but modifications at the C4 in Cring with bulkier groups enhance anticancer activity. NK611, GL331 and Etoposide phosphate are water soluble derivatives of Etoposide with potent anticancer activity and are currently in clinical trials.

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Shipping & Returns

Shipping
We ship your order within 2–3 business days for USA deliveries and 5–8 business days for international shipments. Once your package has been dispatched from our warehouse, you'll receive an email confirmation with a tracking number, allowing you to track the status of your delivery.

Returns
To facilitate a smooth return process, a Return Authorization (RA) Number is required for all returns. Returns without a valid RA number will be declined and may incur additional fees. You can request an RA number within 15 days of the original delivery date. For more details, please refer to our Return & Refund Policy page.

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Warranty

We provide a 2-year limited warranty, from the date of purchase for all our products.

If you believe you have received a defective product, or are experiencing any problems with your product, please contact us.

This warranty strictly does not cover damages that arose from negligence, misuse, wear and tear, or not in accordance with product instructions (dropping the product, etc.).

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